10 Best PCOS Supplements
PCOS is the most frequent cause of female infertility, accounting for around 20% to 25% of all cases. While the symptoms of PCOS vary by person, some of the significant features directly affect a woman’s capacity to conceive. PCOS may result in hormonal abnormalities that interfere with ovulation patterns and, in difficult situations, anovulation. Fortunately, research indicates that various supplements and vitamins may assist women with PCOS manage hormonal imbalances, stimulating ovulation and enhancing female fertility.
We will discuss the ten greatest supplements for PCOS and increasing fertility in this post!
Inositol, also referred to as vitamin B8, is almost certainly the most critical supplement to take if you have PCOS and are attempting to conceive. It makes no difference whether you try naturally or via therapies like IVF. Even if you are not trying to conceive, inositol is an essential vitamin to consider, and this is why.
Around 70% of people with PCOS have detectable levels of insulin resistance. Insulin resistance may seem unrelated to PCOS or infertility, but it is.
Insulin resistance may result in elevated insulin levels, which stimulate the ovaries to generate more androgen hormones such as testosterone and change the luteinising hormone (LH) ratio to follicle-stimulating hormone (FSH). Hormonal abnormalities of this kind may damage egg development and cause ovulatory cycles to be disrupted.
Myo-inositol treatment in women with PCOS
As it turns out, inositol is well-known for its ability to boost insulin receptor activation and reverse insulin resistance. This is particularly critical for persons with PCOS since their inositol levels usually are lower.
As previously stated, myo-inositol may help reduce insulin resistance by roughly 70%, this assists in restoring the hormone ratio essential for ovulation to occur.
In another research, although a small one, inositol was demonstrated to be capable of reviving ovarian function, hence aiding in improving fertility in women with PCOS.
The Effect of Inositol on Menstruation, Ovulation, and Pregnancy Rates in Patients with Polycystic Ovary Syndrome
Inositol supplementation has also been found to improve the quality of oocytes and embryos. Researchers divided individuals with PCOS undergoing IVF into a control and an inositol therapy group in one trial. 136 oocytes were fertilised from the 233 obtained in the inositol group (58.3 per cent). Only 128 of the 300 oocytes generated for the control group were fertilised (42.6 percent).
Supplements with Inositol for PCOS – Embryo Fertilization
Additionally, the inositol therapy group received a more significant number of grade I embryos. Thus, the researchers concluded that inositol treatment improves fertility rates and embryo quality in women with PCOS.
As one may expect, superior embryo quality is connected with increased conception rates. Numerous studies have shown that inositol supplementation results in considerably enhanced clinical pregnancy rates.
In Australia, Myo Inositol is regularly available in capsule or powder form. An Australian Inositol study has shown that using Myo-Inositol & D-Chiro Inositol Blended supplements increased their chance of falling pregnant while also balancing their fertility hormones.
Oil from fish
Fish oil supplements have been linked to many health advantages for women of all ages, including those with PCOS. Fish oil supplementation has improved ovulation, ovarian reserve, and overall fertility. As with myo inositol, fish oil may help alleviate insulin resistance in PCOS patients.
Inflammation is another significant aspect of PCOS that has a detrimental effect on fertility. Due to its anti-inflammatory characteristics, fish oil is a helpful supplement for PCOS sufferers. Additionally, fish oil pills may assist women with PCOS in lowering their bad cholesterol.
Vitamin D Supplements for Polycystic Ovary Syndrome
Between 67 and 85 percent of women with PCOS are vitamin D deficient. Vitamin D deficiency may exacerbate the symptoms of Polycystic ovary syndrome, which include insulin resistance and ovulatory abnormalities, infertility, hyperandrogenism, and obesity. Vitamin D supplementation has been found to improve menstrual regularity and ovulation.
According to one research, women with enough vitamin D levels had a 52.5 percent likelihood of pregnancy for each IVF cycle, compared to 34.7 percent for those with insufficient levels.
Acetyl-Cysteine N-Acetyl-Cysteine (NAC)
The body utilises N-Acetyl-Cysteine (NAC) to synthesise anti-oxidants. Antioxidants generated by NAC aid in the protection and repair of our cells. By preventing cell damage, NAC aids in the battle against inflammation and oxidative stress, both of which may be detrimental to fertility. Because NAC is not present naturally in many foods, it must be obtained via supplementation.
NAC may assist women with Polycystic ovary syndrome improve their insulin sensitivity, decreasing testosterone levels, controlling ovulation, and increasing fertility. Indeed, research has shown that NAC is even more effective in improving insulin resistance than metformin (a drug widely used to treat PCOS). NAC may help to stimulate ovulation and control your menstrual cycle by lowering testosterone levels. Reduced testosterone also aids in the treatment of frequent secondary PCOS symptoms such as acne and excessive facial hair growth.
NAC has been shown to significantly boost the odds of PCOS patients becoming pregnant in terms of fertility enhancement. The researchers conducted a meta-analysis of many trials examining the impact of NAC supplementation on individuals with PCOS (over 910 women). They found that when Polycystic ovary syndrome patients were treated with NAC, their chances of having live birth, becoming pregnant, and ovulating were significantly increased compared to the placebo group.
Supplements with Carnitine for PCOS
Acetyl L-Carnitine (ALC) is a naturally occurring antioxidant in the body, and ALC aids the body in converting fat to energy. According to a clinical investigation, non-obese women with PCOS had lower L-carnitine levels than those without PCOS. Low ALC levels may be associated with hyperandrogenism and insulin resistance, two characteristics frequent in people with PCOS.
A clinical investigation in women with PCOS discovered that combining ALC with clomiphene (a commonly used reproductive treatment intended to promote ovulation in PCOS patients) resulted in a thicker endometrium and increased conception rates.
Magnesium is required for the activity of nearly 300 enzymes in the human body, including glucose metabolism. Surprisingly, more than 75% of all Australians do not fulfil their daily magnesium need via food alone. Additionally, patients with Polycystic ovary syndrome have a 19-fold increased risk of magnesium deficiency compared to the general population.
Low magnesium levels may exacerbate insulin resistance, impairing hormonal balance and communication. As discussed earlier, hormonal abnormalities are particularly frequent in PCOS patients and impair various aspects of reproduction.
Magnesium supplementation may help improve insulin resistance, decrease inflammation, and alleviate PMS symptoms in PCOS patients.
Numerous studies indicate that a number of the frequent symptoms of PCOS, including as insulin resistance, elevated sex hormone levels, and obesity, may have a detrimental effect on the variety and composition of the gut microbiota. The gut bacteria are crucial for nutrition metabolism and preserving the gut’s structural integrity.
Probiotics are living microorganisms that may aid in gut health restoration and improvement. Gut health is critical for inflammation control. Inflammation is a frequent symptom of PCOS and a significant factor in developing insulin resistance.
Probiotic supplements have improved gut health, decreased inflammation, and corrected hormonal imbalances in patients with polycystic ovary syndrome.
By stabilising the menstrual cycle and reducing androgen levels, probiotic supplements may also assist with other symptoms of PCOS.
Zinc (Zn) is a potent antioxidant that aids in regulating several enzymes’ activity and has a role in regulating cell development, hormone synthesis, and reproduction.
While zinc insufficiency is relatively rare in Australia, it is more frequent among females with PCOS. Zn deficiency has been linked to many common PCOS symptoms, including insulin resistance and elevated cholesterol levels.
Zn therapy improves various indices in women with PCOS, most notably those linked to insulin resistance. Additionally, zinc may aid in the correction of hormonal abnormalities and ovulation.
Additionally, zinc supplementation may assist with other frequent PCOS symptoms such as acne, hair growth, weight control, and hair loss.
Supplements with B Vitamins for PCOS
B vitamins come in various forms, but the most critical for PCOS sufferers are vitamin B12 and folate (B9). Both B vitamins reduce inflammation by degrading the homocysteine, and Homocysteine levels are often increased in people with PCOS.
Homocysteine levels over the recommended threshold are related to decreased fertility in various ways, including miscarriage, poor oocyte quality, hypertension, and low birth weight.
Additionally, B vitamins may assist in resolving hormonal imbalances and enhancing fertility in other ways. Supplementation with folate has been shown to raise progesterone levels and decrease the chance of anovulation. Additional research on the effects of nutrition on reproduction has demonstrated that folate is required for oocyte quality and growth, implantation, foetal growth, and organ development.
Coenzyme Q10 Coenzyme Q10 (Co-Q10)
Co-Q10 has been shown to have several beneficial benefits on female fertility in people with and without PCOS. Pre-supplementation with Co-Q10 has enhanced ovarian responsiveness in women having IVF therapy. Additionally, Co-Q10 has been proven to help address age-related reasons for infertility, such as decreased oocyte number and quality.
Besides promoting general fertility, Co-Q10 provides unique advantages for people with PCOS. It has been shown that Co-Q10 has a beneficial impact on insulin and testosterone levels.
The Bottom Line on PCOS Supplements
Although Polycystic ovary syndrome is the most prevalent cause of infertility, it is not impossible to conceive with PCOS! Adhering to a fertility-friendly diet and supplementing with important nutrients such as inositol, vitamin D, fish oil, and magnesium, among others, may help naturally boost fertility.
In addition to taking the supplements mentioned in this article, Polycystic ovary syndrome sufferers may improve their chances of becoming pregnant by completing a fertility consultation and discussing available drugs (such as Letrozole and Clomid) IUI, and IVF with a fertility expert.