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How Metformin Is Used for Fertility

How Metformin Is Used for Fertility

Particular health conditions require specific medications to help treat and reverse the symptoms. Illnesses like diabetes, blood pressure, nerve issues, and others require one to follow through on prescriptions given to them by their doctors. Metformin is also known by its long medical name N,N-dimethyl biguanide. It is a medication that can treat infertility and even reduce the symptoms of polycystic ovarian syndrome (PCOS).

Infertility problems are unpredictable as you may be healthy and have no apparent symptoms but still have difficulty conceiving. You might be unable to find solutions to why you are struggling to fall pregnant.

Infertility treatments vary depending on the seriousness of the problem, which is why fertility doctors use off-label medications like metformin. There is always a solution to everything, and the same applies to infertility as most people try to the verge of giving up.

Ovulation kits and other conceiving-related things are at your disposal whenever you want to use them. Without further ado, let’s explore metformin and its use for fertility.

Can metformin help to get pregnant?
Can metformin help to get pregnant?

What is Metformin?

Metformin is a drug used to treat diabetes and treat infertility. Primarily, metformin is for diabetes patients but can help one achieve pregnancy. It is unclear how metformin does this, but success stories show that this medication can increase your chances of conception. PCOS patients do well with metformin as it helps better their insulin resistance and stabilises their blood glucose levels which can help get their ovulation back on track and potentially increase the frequency of menstrual cycles. Metformin has changed the lives of many people who were trying to conceive, even though it is not a conceiving drug.

How does metformin work?

There is a connection between insulin resistance and metformin. People who suffer from PCOS are resistant to insulin which causes the body to trigger the production of more insulin, which ends up being in excess. There is a connection shared between reproductive hormones and insulin as increased insulin levels steer high levels of androgens.

Androgens are considered male hormones, and when they appear in a female body, they can usher in PCOS symptoms and issues with ovulation. Metformin is used to lower the insulin level in the body to get rid of these hormones. Allowing your ovulation to restart, and you can now start trying to conceive.

How long does metformin take to work for fertility?
How long does metformin take to work for fertility?

What are the benefits of metformin for fertility?

There are different reasons associated with the use of metformin, and some are fertility-related and they are;

  • Ovulation induction

Irregular ovulation is frustrating as one cannot manage to keep track of their menstrual cycles, which can affect your conceiving plans. Metformin can correct this by making your cycles and ovulation days regular. Some doctors do not believe in using metformin for PCOS, although it is beneficial.

  • Insulin resistance

Too much increase in insulin levels affects the reproductive system as it causes the production of unwanted hormones that affect conceiving. Metformin does help regulate hormones meant for reproduction and also restart ovulation. All these contribute to fertility as there is nothing related to hormones hindering you from going ahead and trying to achieve pregnancy.

  • Clomid resistance

Clomid-resistant people can rely on metformin to improve the success rate of Clomid working on those with PCOS leading them to ovulate. Three to six months before starting your Clomid treatment, one should take metformin. Combining metformin with letrozole is also another way of dealing with this.

  • Reduce miscarriages

PCOS patients are likely to have a miscarriage, and one can reduce the chances of this taking place by using metformin. Few studies claim that it works well on patients with PCOS reducing their risk of getting miscarriages. Other studies show that metformin does not reduce the chances of miscarriages, so you need to have a lengthy conversation with your doctor concerning this.

  • Injectable fertility medications

Sometimes, Clomid may not help one get pregnant, and this is where you need to follow through to the next step, which is injectable medications for conceiving. Injectable fertility medications are combined with metformin to improve your pregnancy rate, thus boosting the live birth rate. As much as injectable fertility medications are effective, it is better when one combines the two.

  • Weight loss

Obesity attracts some diseases, and maintaining the right weight for your body, especially when PCOS, is not manageable. Metformin is the perfect alternative for PCOS patients to lose weight and, in turn, improve their fertility chances. Along with using different diet plans and an exercise plan, one can improve their success rate of conceiving.

  • Reduced risk for ovarian hyperstimulation syndrome

The development of Ovarian hyperstimulation syndrome (OHSS) can occur in those people using conceiving medications, especially if they have PCOS. Metformin can be used to reduce the risk of this condition during IVF.

How do you take metformin for ovulation?
How do you take metformin for ovulation?

Myo Inositol vs Metformin for fertility

As much as PCOS patients can receive benifits from taking metformin when trying to conceive, it does not necessarily mean it will result in falling pregnant. Its ability to increase ovulation is commonly confused with fertility medication. 

Metformin alone, though significant, can lack the strength needed for fertility, so one can combine this drug with either Clomid or Letrozole to increase the chances of fertility.

Over-the-counter supplements are also effective for boosting fertility, for example, myoinositol, which can be found in sesame seeds, fruits, beans, and many other foods.

Taking Myo inositol in a supplement form is a good idea as you will not experience any gastrointestinal side effects like metformin. It is not up to you to decide whether or not to start using any supplement like this can be dangerous to you, and that is why consulting your doctor on the topic is always recommended.

Myo Inositol in Australia is available without a prescription, and the most common way to buy Myo inositol is online in capsule form.

About one fourth of women taking have gastrointestinal side effects such as abdominal discomfort, diarrhea and nausea
About one-fourth of women taking metformin have gastrointestinal side effects such as abdominal discomfort, diarrhea and nausea.

What are the side effects?

Every drug possesses its side effects when taken and what differentiates them is the severity of the side effects. Metformin has several side effects, such as;

  • Stomach upset leading to diarrhea
  • Vomiting and nausea
  • Gastrointestinal problems
  • Severe effects like liver dysfunction should stop one from using the drug
  • Lactic acidosis

One should take metformin during the day as this is one way of reducing the side effects. Your doctor must monitor your liver and kidney functioning when on metformin, and this medication is not for persons with liver, heart, kidney, and lung diseases. Provide a complete medical history to your doctor before deciding if metformin is the right choice for you and your fertility journey.


Winding up, doctors do not always share the same thrill for metformin as we do; they have different views on how this medication should be used. PCOS patients benefit the most from using metformin as it is a chance to conceive even with their condition. It is not clear that people with PCOS should use this medication to prompt ovulation, as different studies do not always support using this off label fertility medication.

Take time to discuss the whole thing with your doctor when getting treatment for PCOS and fertility issues, as this does shed light on the entire metformin thing.