Polycystic ovary syndrome , also known as PCOS, impacts many women worldwide. This blog will discuss the nine best supplements for those suffering from PCOS and how they can help increase fertility. Unfortunately, one in 10 women are affected by PCOS during their reproductive years. While the symptoms of PCOS vary by person, some of the significant ones directly affect a woman’s capacity to conceive. PCOS may result in hormonal abnormalities that interfere with ovulation patterns and, in difficult situations, anovulation . Fortunately, various supplements and vitamins may assist women with PCOS in managing hormonal imbalances, stimulating ovulation and enhancing female fertility .

1. Inositol

Inosito , or vitamin B8, is one of the most critical supplements to take if you have PCOS and are attempting to conceive naturally or via therapies like IVF. Even if you are not trying to conceive, inositol is an essential vitamin to consider if you have been diagnosed with PCOS. Many people with PCOS have detectable levels of insulin resistance , which is related to infertility. Insulin resistance may result in elevated insulin levels, which stimulate the ovaries to generate more androgen hormones (such as testosterone) and change the luteinising hormone (LH) ratio to follicle-stimulating hormone ( FSH ). Hormonal abnormalities of this kind may damage egg development and disrupt ovulatory cycles.

Myo-inositol Treatment in Women With PCOS

Inositol is well-known for its ability to boost insulin receptor activation and reverse insulin resistance. This is particularly critical for persons with PCOS since their inositol levels are usually lower. Myo-inositol may help reduce insulin resistance, which assists in restoring the hormone ratio essential for ovulation. A recent study conducted in 2023 has demonstrated that Inositol is a highly effective and safer alternative to Metformin for treating Polycystic Ovary Syndrome (PCOS). The research indicates that Inositol not only matches the efficacy of Metformin but also results in fewer side effects, making it a preferable treatment option.

Supplements with Inositol for PCOS – Embryo Fertilisation

As expected, superior embryo quality is connected with increased conception rates. Numerous studies have shown that inositol supplementation significantly enhances clinical pregnancy rates . In Australia, myo-inositol is regularly available in capsule or powder form.

2. Fish Oil

Fish oil supplements typically contain two key omega-3 fatty acids: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). EPA is particularly effective in reducing inflammation by modulating pro-inflammatory mediators, while DHA supports improved cell membrane function and enhances insulin sensitivity. Together, these fatty acids promote metabolic health, help lower bad cholesterol, and support hormonal balance. For women with PCOS, this dual action can improve ovulation, ovarian reserve, and overall fertility by addressing both inflammation and insulin resistance.

3. Optimising Vitamin D Levels: Testing, Targets, and Safe Sun Exposure

Maintaining optimal vitamin D levels supports hormonal balance and reproductive health, especially for those with PCOS. Australian guidelines advise keeping serum 25-hydroxyvitamin D above 50 nmol/L, while many experts recommend an optimal range of 75 to 100 nmol/L for better endocrine function and ovarian health. Regular testing helps monitor your levels and tailor supplementation to your needs, as excessive vitamin D can cause hypercalcemia and other health issues.

Alongside supplements, responsible sun exposure naturally boosts vitamin D. In Australia, 10 to 15 minutes of midday sun on the face, arms, and hands, two to three times weekly, maintains healthy levels. Balance this with protection by applying sunscreen after the initial minutes to prevent skin damage. Skin type, location, and lifestyle affect vitamin D synthesis, making personalised advice from a healthcare provider essential for a safe and effective plan.

Adequate vitamin D levels are essential for maintaining hormonal balance and optimal reproductive health in women with PCOS. Research has shown that vitamin D insufficiency may worsen symptoms such as insulin resistance, irregular menstrual cycles, and infertility. At the same time, sufficient levels can promote improved ovarian function and better fertility outcomes.

Before starting any vitamin D supplementation, it is important to have your serum vitamin D levels tested and to consult with a healthcare provider. This personalised approach helps ensure that you receive the right dosage tailored to your needs, reducing the risk of potential side effects from excessive intake, such as hypercalcemia. Partnering with a medical professional will also help integrate vitamin D supplementation into a comprehensive treatment plan for managing PCOS and enhancing fertility in a safe, effective manner.

Vitamin D deficiency may exacerbate polycystic ovary syndrome symptoms, including insulin resistance and ovulatory abnormalities, infertility, hyperandrogenism, and obesity. Supplementation has been found to improve menstrual regularity and ovulation. According to one study , women with sufficient vitamin D levels experienced a 52.5% likelihood of pregnancy for each IVF cycle, compared to 34.7 %for those with insufficient levels.

4. Acetyl-Cysteine (NAC)

N-Acetyl-Cysteine (NAC) is a proven antioxidant that boosts glutathione production—a key compound that reduces oxidative stress and inflammation, both linked to hormonal imbalances in PCOS. By improving insulin sensitivity and regulating testosterone levels, NAC can support regular ovulation and enhance reproductive health.

The typical daily dose of NAC ranges from 600 mg to 1,800 mg, taken in two or three divided doses. Healthcare professionals often recommend starting with 600 mg per day and adjusting the dose based on tolerance and medical advice. Taking more than the recommended amount may cause side effects like nausea, diarrhea, or stomach cramps.

According to Australian healthcare guidelines, consult a registered healthcare provider before starting or changing your NAC regimen. Professional guidance ensures the dosage suits your needs and avoids interactions with other medications, maximising safety and benefits.

7. Zinc

Zinc (Zn) is an essential trace mineral vital for enzyme regulation, cell growth, hormone synthesis, and reproductive health. It acts as a powerful antioxidant and supports immune and skin health. A zinc deficiency may present as:

• Hair loss
• Changes in nail colour and strength
• Diarrhoea
• Loss of appetite
• Eye issues
• Delayed wound healing

For women with PCOS, maintaining optimal zinc levels can enhance insulin sensitivity and balance hormones, easing symptoms like acne and unwanted hair growth. Choose zinc supplements with high bioavailability, such as zinc picolinate or zinc citrate, which are better absorbed and effective in managing PCOS-related symptoms.

Boost your zinc intake through foods like oysters, lean beef, pumpkin seeds, and legumes to support overall health and fertility.

8. Supplements With B Vitamins

B vitamins come in various forms, but the most useful types for PCOS sufferers are vitamin B12 and folate (B9). Both B vitamins reduce inflammation by degrading homocysteine levels, which are often increased in people with PCOS. Homocysteine levels over the recommended threshold are related to decreased fertility, including miscarriage, poor oocyte quality, hypertension , and low birth weight. Additionally, B vitamins may assist in resolving hormonal imbalances and enhancing fertility in other ways. Supplementation with folate has been shown to raise progesterone levels and decrease the chance of anovulation. This makes it an excellent supplement for people with PCOS if they need to balance their hormones or are trying to conceive.

9. Coenzyme Q10 Coenzyme Q10 (Co-Q10)

Co-Q10, also known as ubiquinone, is a coenzyme family found in many animals, most types of bacteria, and foods such as meat, poultry, and eggs. It has been shown to have several fertility benefits for people with and without PCOS. Pre-supplementation with Co-Q10 has enhanced ovarian responsiveness in women having IVF therapy. Besides promoting general fertility in men and women, Co-Q10 provides unique advantages for people with PCOS. It has been shown that Co-Q10 has a beneficial impact on insulin and testosterone levels.

10. Chromium

Chromium is a trace mineral that plays a pivotal role in enhancing insulin’s action in the body. Insulin resistance is common in women with PCOS, leading to elevated blood sugar levels and hormonal imbalances. Supplementing with chromium can improve insulin sensitivity, thereby aiding in the regulation of blood sugar levels. This, in turn, can mitigate some of the metabolic symptoms associated with PCOS, such as weight gain and irregular menstrual cycles.

11. Berberine

Derived from various plants, berberine is a bioactive compound known for its anti-inflammatory and anti-diabetic properties. Studies have shown that berberine can be as effective as some pharmaceuticals in regulating glucose metabolism. For women with PCOS, this is particularly beneficial as it not only helps in managing insulin resistance but also improves fertility outcomes. A 2023 study found that berberine has been found to improve ovulatory function and increase the chances of a successful pregnancy.

12. Saw Palmetto

This herbal supplement is commonly used to manage elevated androgen levels in women with PCOS. High levels of androgens can lead to symptoms like hirsutism (excessive hair growth), acne, and menstrual irregularities. Saw Palmetto acts by inhibiting the activity of the enzyme 5-alpha reductase , which is involved in the conversion of testosterone to its more potent form, dihydrotestosterone (DHT). Doing so helps manage these symptoms effectively. However,

13. Evening Primrose Oil

Rich in essential fatty acids like gamma-linolenic acid (GLA), Evening Primrose Oil is often recommended for hormonal balance. The fatty acids present in this oil are precursors to prostaglandins, which are lipid compounds that have hormone-like effects. Prostaglandins play a role in regulating the menstrual cycle and improving the health of the reproductive system. Additionally, the oil has anti-inflammatory properties that can alleviate some PCOS symptoms.

14. Alpha-Lipoic Acid (ALA)

This naturally occurring anti-oxidant is present in many foods and is available as a supplement. ALA is known for its ability to improve insulin sensitivity and regulate blood sugar levels, which are both crucial for managing PCOS symptoms. By enhancing the body’s response to insulin, ALA helps reduce the metabolic symptoms associated with PCOS, such as weight gain and high cholesterol levels.

What does CoQ10 do for hormones?

Selecting High-Quality Supplements

• Choose products tested by accredited laboratories : Ensure they meet Australia’s strict TGA and FSANZ standards.
• Look for clear certification marks : Such as TGA approval and FSANZ endorsement, prominently displayed on the packaging.
• Ensure full ingredient transparency : Check that every component and its exact dosage are listed on the label.
• Purchase supplements from established, reputable Australian suppliers : They should follow rigorous quality control and safety protocols.
• Consult a healthcare professional : Personalise your supplement choices and verify their suitability based on the latest scientific evidence.

Supplement Interactions with Medications

Combining supplements with prescribed treatments requires understanding potential interactions to ensure your safety and treatment effectiveness. Below is a clear overview of common interactions:

Diabetes and Blood Sugar Management

• Inositol, chromium, and berberine can boost diabetes medications, potentially causing hypoglycaemia.
• Monitor blood sugar levels closely and adjust medications with your healthcare provider’s guidance.

Cardiovascular and Blood-Thinning Considerations

• Fish oil has mild blood-thinning effects that may interact with anticoagulant or antiplatelet drugs, increasing bleeding risk.
• Regularly check for signs of excessive bleeding when using these treatments together.

Hormonal and Calcium Metabolism Treatments

• Vitamin D supplements can affect calcium levels and interact with certain hormone therapies, requiring periodic blood tests.
• Saw palmetto impacts androgen metabolism; if you’re on hormone treatments, discuss possible adjustments with your provider.

Gastrointestinal and Absorption Issues

• N-Acetyl-Cysteine (NAC) may cause mild stomach discomfort, potentially affecting the absorption of oral medications.
• If you experience ongoing digestive issues, consult your healthcare professional for advice.

Important Safety Considerations

• Always inform your medical team about all supplements you’re taking, especially alongside prescription medications.
• Dosage adjustments or extra monitoring may be needed to ensure effectiveness and safety.
• Consult reputable health experts to tailor your supplement regimen to your treatment plan.

Trust Fertility2Family for Evidence-Based Support

Fertility2Family provides guidance and products that meet Australian regulatory standards. Our recommendations and supplements comply with the Therapeutic Goods Administration (TGA) and Food Standards Australia New Zealand (FSANZ) guidelines, ensuring exceptional safety, efficacy, and quality.

At Fertility2Family, we believe a personalised approach—combining balanced nutrition, targeted supplementation, and professional medical advice—overcomes the challenges of PCOS. Every strategy we recommend is supported by strong scientific evidence and endorsed by leading reproductive health experts.

With Fertility2Family, you receive trusted, quality-assured solutions designed to empower your fertility journey. Consult your healthcare provider to tailor these evidence-based practices to your unique needs.

Evan kurzyp

Evan Kurzyp

Evan is the founder of Fertility2Family and is passionate about fertility education & providing affordable products to help people in their fertility journey. Evan is a qualified Registered Nurse and has expertise in guiding & managing patients through their fertility journeys.